Who we are
COME is a non-profit foundation looking to establish international and multidisciplinary partnerships to pursue grant funding, high quality research, clinical and health care support.
What we do
We identify meaningful research topics and research teams that can rigorously answer questions. The outcomes of the research supported by the foundation will help people live healthier and more productive lives.
National centres (NACE)
The COME National Centres (NACE) are the local (national) appendices of the foundation and are one of the core components of the Collaboration.
Courses and Webinars
Our courses and webinars provide expert-led, interactive learning experiences designed to enhance your knowledge and skills in various fields. With flexible formats and up-to-date content, they will gain practical insights and tools to excel in the professional journey.
Foundation info
The COME Collaboration is an interdisciplinary foundation for osteopathy excellence.
We bring together clinicians and scientists who study the effect and effectiveness of osteopathic medicine. Our goal is to understand how osteopathy works, to produce compelling evidence to optimize health care services and enhance quality of education. Our research groups study all aspects of application of osteopathic medicine including lab-based and clinical-based research as well as translational research.
We host and train clinicians, scientists and support staff, and interact with collaborators throughout the world.
As well as conducting scientific research, we offer a wide range of educational and training opportunities to support the development of osteopathy both nationally and internationally, and have an active public engagement agenda.
Within the foundation, the terms osteopathy and osteopathic medicine are used interchangeably.
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13 May 2025
Acute changes in functional connectivity associated with first osteopathic manual treatment in chronic low back pain spatially overlap with opioid receptor expressionOsteopathic Manipulative Treatment (OMT) has emerged as a therapeutic approach for chronic low back pain (cLBP). Previous Magnetic Resonance (MR)…
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12 May 2025
Alignment between the research question, design and terminology is required in manual therapy trials – a methodological study.This methodological study aimed to assess the design, reporting, and risk of bias in effectiveness trials in manual therapy, comparing…
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9 May 2025
Placebo effects in osteopathy and other manual therapies – What they are and why they matter to clinical practice, education, and researchPlacebo effects are measurable changes in health outcomes arising from treatment context, driven by learning and expectancy mechanisms. While increasingly…
Last New COME Reseach
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13 May 2025
Acute changes in functional connectivity associated with first osteopathic manual treatment in chronic low back pain spatially overlap with opioid receptor expression
Osteopathic Manipulative Treatment (OMT) has emerged as a therapeutic approach for chronic low back pain (cLBP). Previous Magnetic Resonance (MR)…
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6 May 2025
Osteopathic diagnosis and treatment of the spine in patients with chronic back pain through the lens of medical infrared thermography: A randomised controlled pilot study
Chronic back pain conditions are highly prevalent worldwide. Osteopathic treatment seems to improve pain and function in this population. However,…
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8 March 2025
Autonomic correlates of osteopathic manipulative treatment on facial functional mapping: an innovative approach based on thermal imaging
Osteopathic manipulative treatment (OMT) has shown efficacy in various clinical conditions and age groups. Understanding its neurobiological, particularly autonomic, mechanisms…












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